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Joseph Longo Selected Research

Fluvastatin

11/2021Quantitative Prostate MRI Analysis Following Fluvastatin Therapy for Localized Prostate Cancer - A Pilot Study.
1/2021The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma.
1/2021Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced N-glycosylation Abundance and Branching.
12/2020A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer.
1/2018Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins.

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Joseph Longo Research Topics

Disease

13Neoplasms (Cancer)
04/2022 - 12/2015
4Prostatic Neoplasms (Prostate Cancer)
04/2022 - 01/2019
2Multiple Myeloma
01/2021 - 10/2020
2Breast Neoplasms (Breast Cancer)
01/2021 - 01/2019
1Neoplasm Metastasis (Metastasis)
01/2021
1Hematologic Neoplasms (Hematological Malignancy)
10/2020
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2020
1Hypoxia (Hypoxemia)
12/2015
1Intestinal Neoplasms (Intestinal Cancer)
09/2015
1Carcinogenesis
09/2015
1Polyps
09/2015
1Colorectal Neoplasms (Colorectal Cancer)
09/2015
1Cardiovascular Diseases (Cardiovascular Disease)
04/2003

Drug/Important Bio-Agent (IBA)

8Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
04/2022 - 11/2016
6Mevalonic Acid (Mevalonate)IBA
01/2021 - 11/2016
5FluvastatinFDA Link
11/2021 - 01/2018
3Proteins (Proteins, Gene)FDA Link
01/2021 - 12/2015
3Pharmaceutical PreparationsIBA
01/2021 - 01/2019
2CholesterolIBA
04/2022 - 01/2019
2Caspase 3 (Caspase-3)IBA
11/2021 - 12/2020
2Oncogene Proteins (Oncogene Protein)IBA
01/2019 - 01/2018
2Transcription Factors (Transcription Factor)IBA
12/2015 - 09/2015
1Polysaccharides (Glycans)IBA
01/2021
1Bortezomib (Velcade)FDA Link
01/2021
1N-AcetylglucosaminyltransferasesIBA
01/2021
1Adenosine Monophosphate (AMP)IBA
10/2020
1Dipyridamole (Persantine)FDA LinkGeneric
10/2020
1Cilostazol (Pletal)FDA LinkGeneric
10/2020
1Cyclic AMP (AMP, Cyclic)IBA
10/2020
1Phosphodiesterase InhibitorsIBA
10/2020
1Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA
10/2020
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
10/2020
1EnzymesIBA
01/2019
1Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA
01/2019
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2019
1SterolsIBA
01/2019
1geranylgeranyl pyrophosphate (geranylgeranyl diphosphate)IBA
01/2018
1Biomarkers (Surrogate Marker)IBA
01/2018
1Zinc Finger E-box-Binding Homeobox 1IBA
01/2018
1farnesyl pyrophosphate (farnesyl diphosphate)IBA
01/2018
1Sorafenib (BAY 43-9006)FDA Link
01/2017
1Therapeutic UsesIBA
11/2016
1Oxygen (Dioxygen)IBA
12/2015
1CateninsIBA
09/2015
1HomocysteineIBA
04/2003
1oxidized low density lipoproteinIBA
04/2003
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
04/2003

Therapy/Procedure

4Therapeutics
11/2021 - 01/2018
1Prostatectomy (Retropubic Prostatectomy)
11/2021
1Aftercare (After-Treatment)
12/2020